Born in Athens, Greece on August 15, 1950. Received his M.D. degree with honours from the Aristotelian University Medical School at Thesaloniki, Greece on 1975. He served as a physician in the Greek Army (1975-77) and completed his internship and Residency in Internal Medicin at the Aristotelian University Medical School in 1982. In the same year, he was awarded a State Scholarship from the Aristotelian University Medical School to continue his postgraduate studies abroad.
He immigrated to the USA in 1982 and became a Fellow in Gastroenterology at Boston University of Medicin. He joined the faculty at Boston University School of Medicine on 1984 as as Instructor in Medicin and Biochemistry, became Assistant Professor of Medicin and Biochemistry (1985-1992) and Associate Professor of Medicin and Biochemistry (1993-present). During his tenure at Boston University, he has been engaged in research to study the mechanism of diarrhea and intestinal inflammation and he also completed his doctoral thesis dissertation from the Aristotelian University Medical School with honors in 1985. He has received research funding from several scientific societies, including the American Gastroenterological Association (1986-89), the Crohn's and Colitis Foundation of America (1992-94) and the National Institutes of Health (1984, 1988 and 1994).
He has been active on Hellenic issues and served on the Board of Directors of several Greek-American Organizations, including the Hellenic Scientists Association of Boston (founding member), the New England Hellenic Medical and Dental Society, and the Working Group for Hellenic Issues. He was recently appointed by the Greek Minister of Health on a committee to reform Medical Education in Greece. He is married to Margarita Hatzinikolaou POthoulakis, M.Ed and has two sons, George 8 and Antonis 5.